London: November 1905. England and the world are changing. As civilization edges towards the horrors of World War I, every day brings new tensions in Europe and technological advances that make Victorian England feel like a distant dream. Into the rooms of Sherlock Holmes come Nikola Tesla and Thomas Edison—with new inventions that will alter the course of human history—only both inventions have gone missing.

Can Holmes, Watson, and Irene Adler somehow unravel the latest diabolical scheme of Marie Chartier—evil daughter of the late Professor Moriarty Can world peace be achieved by the most powerful weapon ever created? Can death itself be overcome by a scientific genius? And can Sherlock Holmes survive the greatest personal loss of his career?